FACILITIES & OTHER RESOURCES
Updated 7 June 2022
Fields Relevant for the Emory Integrated Genomics Core (EIGC)
The Emory Integrated Genomics Core (EIGC), one of the Emory Integrated Core Facilities (EICF), consists of three teams which provide unique services to Emory clinical and basic researchers. The central mission of the EIGC is to provide a top-tier genomics resource that is widely available to the Emory research community and that integrates cutting-edge genomics technologies with downstream analyses. The EIGC’s CLIA Team (CLIA: 11D1086150) provides nucleic acid isolation and QC services and cell line validation. The CLIA team provides support for clinical trials research using genomics technologies that need to be conducted in a CLIA certified environment with CLIA validated protocols. Aliquots of human samples isolated in the EIGC can also be transferred to other CLIA/CAP certified testing facilities for clinical diagnostic testing. The EIGC’s Research Team provides a wide variety of genomics services which include genotyping assays like the Infinium Methylation EPIC array and TaqMan Genotyping assays; library preparation for 16S rDNA microbiome, targeted sequencing (Fluidigm Access Array), single cell sequencing (10X Genomics), RNAseq, ATACseq, and reduced representation bisulfite sequencing; Illumina-based Next-Generation sequencing using the Illumina MiSeq and NextSeq platforms; structural variant characterization (Bionano Saphyr; and expression analysis (Nanostring nCounter); spatial profiling services using Visum (10X Genomics) and GeoMx (Nanostring) platforms. The EIGC has adopted an innovative business model whereby large-scale next-generation sequencing is outsourced to other academic and commercial entities, with the ultimate goal of obtaining the lowest cost, highest quality, and fastest turn-around for our customers. The EIGC’s Genome Engineering Team offers custom cloning services and cell line validation of genome edited cells for Emory investigators in support of functional genomics applications.
The EIGC teams include four PhD-level scientists, providing expertise on genomics platforms, epigenetics services, cancer biology, CLIA protocol, custom cloning, genome editing, and other support. The lab is supported by 7 additional staff. The Core director (Dr. Lyra Griffiths) and Scientific director (Dr. Christopher Scharer) provide project planning and grant application support. EIGC works closely with the Emory Integrated Computational Core (EICC) and the Biostatistics Shared Resource at Winship Cancer Institute in order to support our investigators with computational support.
The EIGC is located in a Clinical Laboratory Improvement Amendments (CLIA) certified laboratory located on the 7th floor of the Woodruff Memorial Research Building, with 2400 square feet of dedicated wet-lab space. The EIGC’s laboratory areas include dedicated pre- and post-PCR spaces. Two chemical fume hoods and a biological safety cabinet are also located within the space. The EIGC is located adjacent to the EICC and common public meeting room space on the 7th floor of the Woodruff Memorial Research Building, allowing for project planning meetings that span both cores and weekly EIGC team meetings.